Archives
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However T DM and associated
2022-05-27
However, T1DM and associated hyperglycemia can adversely affect the structure and function of the heart in several mechanisms including inhibiting the anabolic effect of insulin due to its deficiency, generation of higher levels of ROS and induction of lipid peroxidation, and subsequent activation o
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br Retrieval requires histamine H receptors in dorsal hippoc
2022-05-27
Retrieval requires histamine H1 receptors in dorsal hippocampus Retrieval is a dynamic process that requires neurotransmitter regulation (Barros et al., 2000, Barros et al., 2001). Recently, histamine, and histaminergic transmission has entered the list of putative neurotransmitter modulators of
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The initial hyperproliferation phase during crypt regenerati
2022-05-27
The initial hyperproliferation phase during crypt regeneration is reminiscent of the effects of Apc loss during tumour initiation and genetic studies show Yap and Taz are also required for adenoma formation in mice [10••, 12•, 13]. Furthermore, Yap activation by Mst1/2 or Sav deletion increases cry
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br Materials and methods br Results
2022-05-27
Materials and methods Results Discussion Numerous studies have identified important roles for HIF-1α in cellular function and dysfunction through its transcriptional activity [4]. A few studies have reported that HIF-1α is translocated to the mitochondria in human and mouse cancer cell line
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br Conflict of interest br
2022-05-27
Conflict of interest Funding This work was supported by the National Institutes of Health MSK Cancer Center Support Grant/Core Grant [P30 CA008748]. The funding source had no involvement in the study design; in the collection, analysis and interpretation of data; in the writing of the report;
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Activation of sGC induces the generation of cyclic guanosine
2022-05-27
Activation of sGC induces the generation of cyclic guanosine monophosphate (cGMP), phosphorylation of protein kinase G (PKG) and changes in activity of effector proteins such as phosphodiesterases (PDE), ion channels and ion pumps [43]. This pathway eventually leads to dilation of PKI-402 (bronchod
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The Fe deficiency treatment significantly increased the
2022-05-27
The Fe-deficiency treatment significantly increased the shoot/root Fe ratios in both WT and transgenic lines (Fig. 5C), which implied that the Fe distribution from root to shoot may be an adaptive mechanism or stress response in tomato plants. Thus, the overexpression of GSNOR had a positive effect
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br Expression profile of GPR
2022-05-26
Expression profile of GPR35 As noted above, initial studies indicated expression of GPR35 in rat intestine [1] and stomach [2]. Subsequent studies have confirmed significant expression levels in the small intestine, colon and stomach, and this might be relevant in the association between a GPR35
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Herein in consider of the high similarity between GR
2022-05-26
Herein, in consider of the high similarity between GR HBP site and AR HBP site, we applied rational drug design strategy to develop AR/GR antagonists based on the chemical structures of antiandrogens and crystal structure of GR. The following bioassay identified Z19 as a dual AR/GR antagonist. Z19 i
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In the absence of HH ligand HH signaling is
2022-05-26
In the absence of HH ligand, HH signaling is actively maintained in a repressed state by the activity of the HH receptor Patched (PTCH). PTCH is a 12-transmembrane domain protein whose intracellular localization is concentrated at the alpha 2 antagonist of the primary cilium, a single antenna-like
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Another consistent observation in our
2022-05-26
Another consistent observation in our studies was the lower plasma catecholamine concentrations in the exercised GHSR-null mice, suggesting a diminished sympathoadrenal response. A proper sympathoadrenal response is essential for increasing substrate utilization during exercise [81]. Thus, the reduc
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The eradication of agonist activity in
2022-05-26
The eradication of agonist activity in compound was also confirmed in the ex vivo growth hormone (GH) release experiment conducted in isolated primary rat pituitary Yeast Extract as shown in . Compound did not produce any noticeable GH secretion at up to 10μM concentration. It could also antagoni
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The role of GJs in liver fibrogenesis
2022-05-26
The role of GJs in liver fibrogenesis was studied recently. Studies showed a significant decrease in liver fibrosis in Cx32 knockout mice compared to wild-type mice. Although the mechanism underlying this protective effect of Cx32 deletion is not clear, reduced oxidative stress was suggested as a po
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In conclusion starting from the weakly potent GSM exploratio
2022-05-26
In conclusion, starting from the weakly potent GSM , exploration of various spacer groups between the triazole ring and the aromatic Ruxolitinib led to the discovery of a new series of potent gamma secretase modulators, with an improved drug-like profile—compared with the originally reported series
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br Novel mechanisms of fipronil resistance in
2022-05-26
Novel mechanisms of fipronil resistance in planthoppers Conclusion Conflict of interest Introduction Methamphetamine, a widely abused drug, is mainly used as a psychostimulant although it is occasionally used at low doses for medical purposes, such as in attention deficit or hyperactivit