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br Acknowledgments We apologize to the researchers who
2021-11-30
Acknowledgments We apologize to the researchers who were not referenced due to space limitations. We thank Dave Primm (Department of Surgery, University of Texas Southwestern Medical Center) for his critical reading of the manuscript. This work was supported by grants from the US National Institu
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br Problem of cellular retention not only affects the cellul
2021-11-30
Problem of cellular retention not only affects the cellular activity of the nanoparticles and nanocomplexes but can also have ramifications in their in vivo applications. While inorganic nanoparticles are being developed extensively for detection as well as treatment of different human diseases, i
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Over the years a number of studies have reported results
2021-11-30
Over the years, a number of studies have reported results concerning the behavior of the two endothelin receptor subtypes, ETA and ETB, that do not fit the classical model of two G protein-coupled receptors acting independently of one another. For example, in the rat anterior pituitary gland, both E
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In the present study fasting blood glucose and insulin
2021-11-30
In the present study, fasting blood glucose and insulin levels were not significantly different between GA patients and control cases. Normal mammalian cells typically acquire fatty acids from the circulation owing to insulin, which is the most lipogenic hormone in the subset of adult tissues, inclu
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In vitro studies suggest that the
2021-11-30
In vitro studies suggest that the increase in Hx activity seen in normal pregnancy may contribute to the down-regulation of the vascular expression of Angiotensin II receptor 1 thereby promoting a relaxed and dilated maternal vascular bed [25]. It has further been suggested that the decreased Hx act
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Let Therefore where F X
2021-11-30
Let Therefore,where F(X) denotes the rate of production of new people who get infected and V(x) represents the motion of individuals in compartments, which gives us Now, the derivative of F and V calculated at an equilibrium point E0 gives matrices f and v of order 6 × 6 defined aswhere Thus, th
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br Introduction Excitatory pyramidal neurons
2021-11-30
Introduction Excitatory pyramidal neurons are generated in the cortical ventricular zone and migrate into the cortical plate alongside the radial glial processes (Chanas-Sacre et al., 2000, Hartfuss et al., 2001, Noctor et al., 2001, Rakic, 1972, Tan et al., 1998). Neuronal migration determines t
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Decreasing GSK activity has therapeutic benefits
2021-11-30
Decreasing GSK-3β activity has therapeutic benefits in animal model of colitis [45] and traumatic Parthenolide injury [46] and ischemia/reperfusion injury [47,48]. In brain, activation of GSK-3β promotes Aβ toxicity by elevating APP expression and its amyloidogenic cleavage, and by dysregulating Aβ
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Any brain damage including that caused by amyloid triggers a
2021-11-30
Any biotin-LC-LC-tyramide damage, including that caused by β-amyloid, triggers activation of microglia, the resident immune cells of the CNS. These cells cluster around amyloid plaques, in which they extend cytoplasmic processes (Combs, 2009). The significance of this response is controversial, but
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Excessive adiposity is also a key pathogenic factor in the
2021-11-29
Excessive adiposity is also a key pathogenic factor in the development of CVD. Through reductions in bodyweight, GPR120 agonism is therefore also implicated as a potential therapy for obesity and heart and vessel disease. In addition to weight loss, when compared with their wild-type littermates, GP
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br Author contribution br Declaration
2021-11-29
Author contribution Declaration of interest Acknowledgements This work was supported by National Natural Science Foundation of China (Grants 81473093) and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM1601ZZ-02). Introduction Diabetes represents a majo
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Given the proposed importance of conformational dynamics
2021-11-29
Given the proposed importance of conformational dynamics to GCK's allosteric regulation, a number of biophysical methods have been utilized to probe the enzyme's dynamic structural landscape. Investigations into the mechanism of those times binding, using changes in the enzyme's intrinsic fluoresc
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The main aim of our study was to identify
2021-11-29
The main aim of our study was to identify whether glucokinase and Irs2 were required for beta cell replication induced by short-term HF diet feeding. Glucokinase plays a critical role in regulating blood glucose levels by catalysing the rate-limiting biochemical reaction of glycolysis [26,27]. In pa
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An advantage of photolabeling with
2021-11-29
An advantage of photolabeling with tritiated photoprobes followed by microsequencing with Edman degradation is the ability to both identify the photolabeled Benazepril HCl and to quantify photoincorporation which enables assessment of pharmacological specificity and allosteric interactions with oth
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Accordingly and in animal models a high fat diet rich
2021-11-29
Accordingly and in animal models, a high-fat diet rich in CO (CO-HFD) impeded ventricular function and induced cardiac cell death and remodeling, at least, by down-regulating cell antioxidant defense systems and induction of oxidative stress [28], [29], [30], [31]. Interestingly, long chain fatty ac